MSc in Human Biology

Presenter:  Lauren Reid

Title of the Thesis:  “Inflammatory Bowel Disease: An Evaluation of Mechanisms and Treatments”

Inflammatory bowel disease (IBD) is an autoimmune disease that causes chronic inflammation and a breakdown of the mucous membrane of the intestinal tract. Its pathology is not fully known, but influencing factors include genetics, microbiome diversity, immune system alterations and environmental factors. An increase in the prevalence of IBD, especially in adolescents, is being observed. This project aimed to gather more information on a common IBD therapeutic, Remicade® (infliximab) as a treatment strategy for adolescents with IBD. An in vitro model was developed to further study this drug, and a systematic review was conducted to evaluate the optimal dosing strategy of Remicade® for adolescents living with IBD. Overall, findings from this thesis provide insight into potential disease models and treatments for IBD. It is an expansion to the already existing body of knowledge surrounding this disease.

April 17, 2025 9:00 am, Don and Marion McDougall Hall, Room 329

Everyone is welcome.