Presenter: Olivier Philips

Title: "Exploring the Functions of Metabolites Downstream of the Serine Biosynthesis Pathway"

Abstract:

This study explores the serine biosynthesis pathway's (SBP) significance as a potential therapeutic target in specific breast cancers. While the SBP's importance in these cancers is acknowledged, its full functions remain unclear. Investigating downstream pathways associated with the SBP aims to shed light on its role, potentially uncovering new treatment targets, and addressing a critical research gap. Using the SBP inhibitor NCT-503, we effectively curbed cell proliferation and impeded serine biosynthesis in SBP-dependent breast cancer cell lines. Metabolomics analysis with NCT-503 revealed significant alterations in vital metabolites like creatine, taurine, glutathione, and GABA. Minimal variations in metabolite abundance were observed across different media types, and interventions involving creatine and its precursor, guanidinoacetic acid, rescued cell growth alongside NCT-503 in SBP-dependent lines. Exploring protein interactors of creatine identified potential targets such as TNPO3, TPP1, MGAT4B, HEATR5B, NPAT, and WDR46, advancing our understanding and uncovering potential therapeutic avenues for breast cancer.

Date/Time/Location: Tuesday, January 9, 2024, 2:00 pm, via web conference

If you wish to attend the public presentation, please contact the Graduate Studies Coordinator at gsc@upei.ca to receive the link.

Everyone is welcome.