Title: "Fluorescence-Based Investigations of 1,8- and 2,6-ANS with Pillar[n]arene, Calix[n]arene, and Cyclodextrin Hosts in Nonaqueous Solvents"

Abstract: The properties and host-guest inclusion complexes of pillar[n]arene, calix[n]arene, and cyclodextrin hosts were investigated in nonaqueous solvents via fluorescence spectroscopy in a comparative binding study. Comparing the inclusion abilities of these families of macrocyclic hosts is particularly interesting as pillar[n]arenes and calix[n]arenes are less frequently used but have chemical similarities, and cyclodextrins are the most popular family of hosts. Two structural isomers, 1,8- and 2,6-ANS, were used as polarity-sensitive fluorescent guests to investigate the effect of guest shape and size on the binding by hosts. Fluorescence titrations were performed in nonaqueous solvents to monitor the formation of inclusion complexes and to determine the binding constants, K, for the various systems. The results of this comparative binding study show that the binding of these ANS guests does not depend on any one factor alone but rather a combination of inter-related factors, including solvent polarity, specific solvent-solute interactions, host cavity shape and size, host flexibility, and available driving forces for inclusion in nonaqueous solvents. This work has contributed to the understanding of host-guest inclusion in nonaqueous solvents and relative host properties.

Everyone is welcome.