TITLE OF THESIS: Folic acid (FA) supplementation impact on Avian B-lymphocyte molecular innate and adaptive immunity gene responses under lipopolysaccharide (LPS) and Infectious Bursal Disease Virus (IBDV) activation

BRIEF ABSTRACT: Folic acid (FA) is a water-soluble vitamin that is known to participate in mechanisms associated with the gene expression of innate and humoral molecular immunity pathways. One of these mechanisms is the methylation of cytosines located in the DNA-CpG islands. Methylation patterns in DNA-CpG islands are known to control the mRNA expression of some genes. Folic acid has been shown to modulate immune responses and gene expression in different sets of cells. Therefore, this manuscript has investigated and demonstrated the FA supplementation effect on chicken B-lymphocyte innate and adaptive immunity gene expression in response to lipopolysaccharides as a bacteria-derived antigen and infectious bursal disease virus (IBDV) as one of the key immunosuppressive viruses in poultry industry.

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