Please join Mahdis Tabatabaei for her Molecular and Macromolecular Sciences Seminar Program presentation entitled " Nanoparticles Based Immuno-PCR Assay for Trace Detection of Biomarkers"

Abstract: Sensitive detection of analytes in biological fluids is critical for early detection of disease and can enhance the timely treatment, management and prevention strategies in clinics. Immuno- PCR is a relatively novel method that combines the two most widely used methods, namely enzyme linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) to create a very sensitive, specific, facile and robust strategy, for detection of small quantities of analytes in biological fluids. Employing nanoparticles in immuno-PCR has the potential to further improve the sensitivity of the assay and gold nanoparticles are one of the most promising nanomaterials for this purpose. Gold nanoparticles are non-toxic, offers large surface area for facile conjugation of variety of biomolecules and possess unique optical and electronic properties, which are useful for a variety of immuno-assays including immuno-PCR. This study is primarily focused on evaluating the role of size of gold nanoparticles to improvise the sensitivity of immuno-PCR assays.

Everyone is welcome to attend!