The UPEI Department of Chemistry invites the campus community to a research seminar on August 14 by Dr. Trevor Clark, Postdoctoral Fellow, Simon Fraser University, who will present "Effective use and integration of HRMS metabolomics for the annotation and discovery of natural products."

Abstract: 

For the last decade, high-resolution mass spectrometry (HRMS) based metabolomics has emerged as the predominant way to analyze complex natural product mixtures. These data can then be integrated with biological assay data to determine priority lists for isolation and elucidation of new bioactive natural products. This presentation will discuss a few in-depth studies exploring the considerations that should be made when collecting HRMS data and discussing how to effectively use those data for the annotation and prioritization of a natural products library. We will then explore some current work applying all we have learnt and developed to a library of 50,000 natural product fractions for the isolation of anti-cancer compounds. Ending then with some future prospective projects in the area of time-based extractions combined with isotope labeling to explore a more comprehensive metabolomics assessment of microorganisms in community environments.

Dr. Clark is a candidate for a tenure-track faculty position in Natural Products Chemistry in the Department of Chemistry.